Constraints on the parameters of the CKM matrix by End 1998

A review of the current status of the Cabibbo-Kobayashi-Maskawa matrix (CKM) is presented. This paper is an update of the results published in [1]. The experimental constraints imposed by the measurements of \epsilon_K, V_{ub}/V_{cb}, \Delta m_d and from the limit on \Delta m_d are used. Values of the constraints and of the parameters entering into the constraints, which restrict the range of the \bar{\rho} and \bar{\eta} parameters, include recent measurements presented at 1998 Summer Conferences and progress obtained by lattice QCD collaborations. The results are: \bar{\rho}=0.202 ^{+0.053}_{-0.059},\bar{\eta}=0.340 \pm 0.035, from which the angles \alpha, \beta and \gamma of the unitarity triangle are inferred : \sin 2 \alpha = -0.26 ^{+ 0.29}_{-0.28} ,\sin 2 \beta = 0.725 ^{+0.050}_{-0.060} ,\gamma= (59.5^{+8.5}_{-7.5})^{\circ}. Without using the constraint from \epsilon_K, \sin 2 \beta has been obtained: \sin 2 \beta = 0.72 ^{+0.07}_{-0.11}. Several external measurements or theoretical inputs have been removed, in turn, from the constraints and their respective probability density functions have been obtained. Central values and uncertainties on these quantities have been compared with actual measurements or theoretical evaluations. In this way it is possible to quantify the importance of the different measurements and the coherence of the Standard Model scenario for CP violation. An important result is that \Delta m_s is expected to be between [12.0-17.6] ps^{-1} with 68% C.L. and <20 ps^{-1} at 95% C.L. Finally relations between the CKM parameters and the quark masses are examined within a given model.Comment: 26 page

Sub-millimeter nuclear medical imaging with high sensitivity in positron emission tomography using beta-gamma coincidences

We present a nuclear medical imaging technique, employing triple-gamma trajectory intersections from beta^+ - gamma coincidences, able to reach sub-millimeter spatial resolution in 3 dimensions with a reduced requirement of reconstructed intersections per voxel compared to a conventional PET reconstruction analysis. This '$\gamma$-PET' technique draws on specific beta^+ - decaying isotopes, simultaneously emitting an additional photon. Exploiting the triple coincidence between the positron annihilation and the third photon, it is possible to separate the reconstructed 'true' events from background. In order to characterize this technique, Monte-Carlo simulations and image reconstructions have been performed. The achievable spatial resolution has been found to reach ca. 0.4 mm (FWHM) in each direction for the visualization of a 22Na point source. Only 40 intersections are sufficient for a reliable sub-millimeter image reconstruction of a point source embedded in a scattering volume of water inside a voxel volume of about 1 mm^3 ('high-resolution mode'). Moreover, starting with an injected activity of 400 MBq for ^76Br, the same number of only about 40 reconstructed intersections are needed in case of a larger voxel volume of 2 x 2 x 3~mm^3 ('high-sensitivity mode'). Requiring such a low number of reconstructed events significantly reduces the required acquisition time for image reconstruction (in the above case to about 140 s) and thus may open up the perspective for a quasi real-time imaging.Comment: 17 pages, 5 figutes, 3 table

A detector of small harmonic displacements based on two coupled microwave cavities

The design and test of a detector of small harmonic displacements is presented. The detector is based on the principle of the parametric conversion of power between the resonant modes of two superconducting coupled microwave cavities. The work is based on the original ideas of Bernard, Pegoraro, Picasso and Radicati, who, in 1978, suggested that superconducting coupled cavities could be used as sensitive detectors of gravitational waves, and on the work of Reece, Reiner and Melissinos, who, {in 1984}, built a detector of this kind. They showed that an harmonic modulation of the cavity length l produced an energy transfer between two modes of the cavity, provided that the frequency of the modulation was equal to the frequency difference of the two modes. They achieved a sensitivity to fractional deformations of dl/l~10^{-17} Hz^{-1/2}. We repeated the Reece, Reiner and Melissinos experiment, and with an improved experimental configuration and better cavity quality, increased the sensitivity to dl/l~10^{-20} Hz^{-1/2}. In this paper the basic principles of the device are discussed and the experimental technique is explained in detail. Possible future developments, aiming at gravitational waves detection, are also outlined.Comment: 28 pages, 12 eps figures, ReVteX. \tightenlines command added to reduce number of pages. The following article has been accepted by Review of Scientific Instruments. After it is published, it will be found at http://link.aip.org/link/?rs

2000 CKM-Triangle Analysis A Critical Review with Updated Experimental Inputs and Theoretical Parameters

Within the Standard Model, a review of the current determination of the sides and angles of the CKM unitarity triangle is presented, using experimental constraints from the measurements of |\epsilon_K|, |V_{ub}/V_{cb}|, \Delta m_d and from the limit on \Delta m_s, available in September 2000. Results from the experimental search for {B}^0_s-\bar{B}^0_s oscillations are introduced in the present analysis using the likelihood. Special attention is devoted to the determination of the theoretical uncertainties. The purpose of the analysis is to infer regions where the parameters of interest lie with given probabilities. The BaBar "95 %, C.L. scanning" method is also commented.Comment: 44 pages (revised version

Constraints on the parameters of the VCKMV_{CKM} matrix at the end of 1997

A review of the current status of the Cabibbo-Kobayashi-Maskawa matrix V_CKM is presented. This paper contains an update of the results published in hep-ph/9711261. Values of the parameters entering into the constraints, which restrict the range for rho and eta parameters, include recent measurements given at 1997 Summer Conferences and progress obtained by lattice QCD collaborations.Experimental constraints imposed by the measurements of epsilon_k,V_ub/V_cb, Delta m_d and by the limit on Delta m_s, are compatible and do not show evidence for New Physics inside measurements errors. Values for the angles alpha, beta and gamma of the C.K.M. triangle have been also obtained: rho=0.156 +- 0.090, eta=0.328 +- 0.054 sin 2alpha = -0.10+-0.40, sin 2beta = 0.68 +- 0.10, gamma= 64+-12 Angles theta,theta_u,theta_d and phi proposed in the parametrisation (Phys. Lett. B5353 (1995) 114.) of the C.K.M. matrix have been also determined. Finally, as there are more constraints than the fitted rho and eta parameters, several external measurements or theoretical inputs have been removed, in turn, from the constraints and their respective values have been fitted simultaneously with rho and eta.Central values and uncertainties on these quantities have been compared with actual measurements or theoretical evaluations. In this way it is possible to quantify the importance of the different measurements and the coherence of the Standard Model scenario for CP violation.Comment: 29 page

Stem Cell Therapy in Ocular Pathologies in the Past 20 Years

Stem cell therapies are successfully used in various fields of medicine. This new approach of research is also expanding in ophthalmology. Huge investments, resources and important clinical trials have been performed in stem cell research and in potential therapies. In recent years, great strides have been made in genetic research, which permitted and enhanced the differentiation of stem cells. Moreover, the possibility of exploiting stem cells from other districts (such as adipose, dental pulp, bone marrow stem cells, etc.) for the treatment of ophthalmic diseases, renders this topic fascinating. Furthermore, great strides have been made in biomedical engineering, which have proposed new materials and threedimensional structures useful for cell therapy of the eye. The encouraging results obtained on clinical trials conducted on animals have given a significant boost in the creation of study protocols also in humans. Results are limited to date, but clinical trials continue to evolve. Our attention is centered on the literature reported over the past 20 years, considering animal (the most represented in literature) and human clinical trials, which are limiting. The aim of our review is to present a brief overview of the main types of treatments based on stem cells in the field of ophthalmic pathologies